The present study was initiated by comparing publicly available transcription profiles of tumor tissues from responsive and resistant ICB-treated patients across various cancer types.

May 10, 2024 · Authors note that tumors likely employ a variety of strategies to evade immune detection. But the discovery could lead to a new approach for targeted cancer therapies.

Mar 22, 2024 · In summary, EV PD-L1 affects both immune cells and tumor cells, leading to the suppression of anti-tumor immunity and promotion of tumor progression. These processes ultimately …

Discover how cancer cells bypass immune defenses and explore innovative strategies to combat the disease through scientific insights and therapeutic approaches.

Identified as a hallmark in 2011, ten years after the seminal “The Hallmarks of Cancer” paper was published in Cell, the concept reflects the critical role the immune system plays in both suppressing …

Oct 1, 2020 · Interactions between immune checkpoints (ICs) and their ligands negatively regulate T cell activation pathways involved in physiological immune respon…

Jun 9, 2025 · The exploitation of immune checkpoints by cancer cells significantly impacts the anti-tumor immune response. The suppression of T-cell activation and proliferation enables cancer cells to …

Yet, tumors employ various mechanisms to evade or counteract attack by immune response components. Some of these mechanisms involve changes in the manifestation of tumor cells, others …

Dec 16, 2025 · Even if a T-cell recognizes a cancer cell, the tumor employs a second strategy to shut down the immune attack through molecular signaling. This involves exploiting natural “brakes” in the …

Jan 22, 2016 · Normally, Drake explains, these checkpoints function to protect the body from auto-immune attack; "but in cancer, tumors hijack those pathways to protect themselves, instead."